Sundqvist et al 1976

#Endo
#EndoStudies
Second step of the endo microbio research

Study Design

• isolated bacteria combinations from root canals of teeth with necrotic pulps and periapical bone destruction
• inoculated subcutaneously in guinea pigs to test for capacity to induce abscess formation and transmissible infections
• transmissible infections
  • could be induced with combinations obtained from teeth with purulent apical inflammation
  • could not be induced with combinations from symptomless teeth with chronic apical inflammation
  • all combinations that induced transmissible infections containes strains of Bacteroides melaninogenicus or B. Asaccharolyticus

Results

• Purulent inflammation in apical region may be induced by specific combinations of bacteria in root canal, particular B melaninogenicus or B asaccharolyticus
  • but, strains needed support of additional microorganisms to achieve pathogenicitiy
• all bacterial combinations induced acute inflammation with accumulation of polymorphonuclear leukocytes and formatoin of an abscess